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1

Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice

Andrew Parkinson, Robert P. Clement, Christopher N. Casciano, Mitchell N. Cayen

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 2.04 MB

english, 1992

2

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Chemistry, Manufacturing, and Controls: The Drug Substance and Formulated Drug Product

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 1.61 MB

english, 2010

3

In vitro metabolism of 10-(3-chlorophenyl)-6,8,9,10-tetrahydrobenzo[b][1,8]naphthyridin-5(7H)-one, a topical antipsoriatic agent. Use of precision-cut rat, dog, monkey and human liver slices, and chemical synthesis of metabolites

Shmuel Zbaida, Yancy Du, Daniel Shannon, Donald Laudicina, C. Mohan Thonoor, Kwokei Ng, Neil Blumenkrantz, James E. Patrick, Mitchell N. Cayen, Richard Friary, Vera Seidl, Tze-Ming Chan, Birendra Pram

Journal:

Biopharmaceutics & Drug Disposition

Year:

1998

Language:

english

File:

PDF, 405 KB

english, 1998

4

Racemic mixtures and single stereoisomers: Industrial concerns and issues in drug development

Mitchell N. Cayen

Journal:

Year:

1991

Language:

english

File:

PDF, 516 KB

english, 1991

5

Loratadine administered concomitantly with erythromycin: Pharmacokinetic and electrocardiographic evaluations*

Brannan, Melvin D., Reidenberg, Pascale, Radwanski, Elaine, Shneyer, Lucy, Lin, Chin-Chung, Cayen, Mitchell N., Affrime, Melton B.

Journal:

Clinical Pharmacology & Therapeutics

Year:

1995

Language:

english

File:

PDF, 942 KB

english, 1995

6

Determination of plasma concentrations of SCH 44643 by a GC method and correlation of plasma concentration and anti-PAF activity in cynomolgus monkeys

Chin-Chung Lin, Motasim Billah, Hong-Ki Kim, Robert Egan, John Anthes, Helen Gilchrest, Mitchell Cayen

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

1996

Language:

english

File:

PDF, 301 KB

english, 1996

7

Tolrestat kinetics

Hicks, David R, Kraml, Michael, Cayen, Mitchell N, Dubuc, Jean, Ryder, Steven, Dvornik, Dushan

Journal:

Clinical Pharmacology & Therapeutics

Year:

1984

Language:

english

File:

PDF, 344 KB

english, 1984

8

Pharmacokinetics and disposition of the lipid-lowering drug acifran in normal subjects and in patients with renal failure

Cayen, Mitchell N, Ferdinandi, Eckhardt S, Hicks, David R, Gonzalez, Ramona, Cosyns, Luc, Dubuc, Jean, Kraml, Michael, Edwards, K David G

Journal:

Clinical Pharmacology & Therapeutics

Year:

1990

Language:

english

File:

PDF, 570 KB

english, 1990

9

A guide to drug discovery: Making Better Drugs: Decision Gates in Non-Clinical Drug Development

Pritchard, J. Fred, Jurima-Romet, Malle, Reimer, Mark L. J., Mortimer, Elisabeth, Rolfe, Brenda, Cayen, Mitchell N.

Journal:

Nature Reviews Drug Discovery

Year:

2003

Language:

english

File:

PDF, 586 KB

english, 2003

10

Characterization of AUCs from Sparsely Sampled Populations in Toxicology Studies

Sudhakar M. Pai, Scott H. Fettner, Gerald Hajian, Mitchell N. Cayen, Vijay K. Batra

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 1.17 MB

1996

11

Drug Metabolites in Safety Testing

Thomas A. Baillie, Mitchell N. Cayen, Hassan Fouda, Ronald J. Gerson, James D. Green, Scott J. Grossman, Lewis J. Klunk, Bernard LeBlanc, Darcy G. Perkins, Lisa A. Shipley

Journal:

Toxicology and Applied Pharmacology

Year:

2002

Language:

english

File:

PDF, 68 KB

english, 2002

12

Reply

Thomas A. Baillie, Mitchell N. Cayen, Hassan Fouda, Ronald J. Gerson, James D. Green, Scott J. Grossman, Lewis J. Klunk, Bernard LeBlanc, Darcy G. Perkins, Lisa A. Shipley

Journal:

Toxicology and Applied Pharmacology

Year:

2003

Language:

english

File:

PDF, 38 KB

english, 2003

13

Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats

Kathleen A. Cox, Kimberly Dunn-Meynell, Walter A. Korfmacher, Lisa Broske, Amin A. Nomeir, Chin-Chung Lin, Mitchell N. Cayen, William H. Barr

Journal:

Drug Discovery Today

Year:

1999

Language:

english

File:

PDF, 200 KB

english, 1999

14

The effect of starvation and cholesterol feeding on intestinal cholesterol synthesis in the rat

Marsha Black, Mitchell N. Cayen

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1969

Language:

english

File:

PDF, 759 KB

english, 1969

15

Studies on the hypolipidemic and estrogenic activities of 2.8-dibenzylcyclooctanone and its analogues

Mitchell N. Cayen, Jean Dubuc, Morris L. Givner, Erminio Greselin, Clara Revesz

Journal:

Biochemical Pharmacology

Year:

1976

Language:

english

File:

PDF, 171 KB

english, 1976

16

Hypolipidemic activity of 2,8-dibenzyl-cyclooctanone in rats

Mitchell N. Cayen, Jean Dubuc, Dushan Dvornik

Journal:

Biochemical Pharmacology

Year:

1976

Language:

english

File:

PDF, 476 KB

english, 1976

17

Pharmacokinetics and hypolipidemic activity of clofibrate-nicotinic acid combinations in rats

Mitchell N. Cayen, William T. Robinson, Jean Dubuc, Dushan Dvornik

Journal:

Biochemical Pharmacology

Year:

1979

Language:

english

File:

PDF, 595 KB

english, 1979

18

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6

Nathan Yumibe, Keith Huie, Kwang-Jong Chen, Mark Snow, Robert P. Clement, Mitchell N. Cayen

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 997 KB

english, 1996

19

Comparative bioavailability of ceftibuten in capsule and suspension forms

Chin-chung Lin, Melton Affrime, Elaine Radwanski, Josephine Lim, Robert Colucci, Mitchell N. Cayen

Journal:

Clinical Therapeutics

Year:

1996

Language:

english

File:

PDF, 400 KB

english, 1996

20

Disposition of 14C-eptifibatide after intravenous administration to healthy men

Kevin B. Alton, Teddy Kosoglou, Susan Baker, Melton B. Affrime, Mitchell N. Cayen, James E. Patrick

Journal:

Clinical Therapeutics

Year:

1998

Language:

english

File:

PDF, 1.06 MB

english, 1998

21

Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man

Mitchell N. Cayen

Journal:

Pharmacology & Therapeutics

Year:

1985

Language:

english

File:

PDF, 3.88 MB

english, 1985

22

Studies on the disposition of diosgenin in rats, dogs, monkeys and man

Mitchell N. Cayen, Eckhardt S. Ferdinandi, Erminio Greselin, Dushan Dvornik

Journal:

Atherosclerosis

Year:

1979

Language:

english

File:

PDF, 1.40 MB

english, 1979

23

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Bioanalytical Strategies

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 1.32 MB

english, 2010

24

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Nonclinical Safety Pharmacology Studies Recommended for Support of First-in-Human Clinical Trials

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 591 KB

english, 2010

25

Early Drug Development (Strategies and Routes to First-in-Human Trials) || ADME Strategies in Lead Optimization

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 826 KB

english, 2010

26

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Estimation of Human Starting Dose for Phase I Clinical Programs

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 975 KB

english, 2010

27

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Good Laboratory Practice

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 804 KB

english, 2010

28

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Exploratory INDs/CTAs

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 556 KB

english, 2010

29

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Toxicology Program to Support Initiation of a Clinical Phase I Program for a New Medicine

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 564 KB

english, 2010

30

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Prediction of Pharmacokinetics and Drug Safety in Humans

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 782 KB

english, 2010

31

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Project Management and International Regulatory Requirements and Strategies for First-in-Human Trials

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 575 KB

english, 2010

32

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Drug Discovery and Early Drug Development

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 542 KB

english, 2010

33

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Unique Considerations for Biopharmaceutics

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 598 KB

english, 2010

34

Early Drug Development (Strategies and Routes to First-in-Human Trials) || Toxicokinetics in Support of Drug Development

Cayen, Mitchell N.

Year:

2010

Language:

english

File:

PDF, 783 KB

english, 2010

35

Foodstuff Flavors, Some Factors Affecting the Flavor of Sodium Caseinate.

Cayen, Mitchell, Baker, Bruce

Journal:

Journal of Agricultural and Food Chemistry

Year:

1963

Language:

english

File:

PDF, 359 KB

english, 1963

36

Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids

Jirkovsky, Ivo, Cayen, Mitchell N.

Journal:

Journal of Medicinal Chemistry

Year:

1982

Language:

english

File:

PDF, 456 KB

english, 1982

37

Synthesis and antihypertensive activity of some thienylethanolamines

Bagli, Jehan F., Mackay, Walter D., Ferdinandi, Eckhardt, Cayen, Mitchell N., Vavra, Ivan, Pugsley, Thomas, Lippmann, Wilbur

Journal:

Journal of Medicinal Chemistry

Year:

1976

Language:

english

File:

PDF, 928 KB

english, 1976

38

Metabolic Disposition of Antihyperlipidemic Agents in Man and Laboratory Animals

Cayen, Mitchell N.

Journal:

Drug Metabolism Reviews

Year:

1980

Language:

english

File:

PDF, 1.62 MB

english, 1980

39

METABOLIC DISPOSITION OF CLOFIBRATE

Cayen, Mitchell N.

Journal:

Drug Metabolism and Drug Interactions

Year:

1980

Language:

english

File:

PDF, 2.11 MB

english, 1980

40

Preface

Cayen, Mitchell N., Hanzlik, Robert P.

Journal:

Year:

1987

Language:

english

File:

PDF, 303 KB

english, 1987

41

The Metabolic Disposition of Etodolac in Rats, Dogs, and Man

Cayen, Mitchell N., Kraml, Michael, Ferdinandi, Eckhardt S., Greselin, Erminio, Dvornik, Dushan

Journal:

Drug Metabolism Reviews

Year:

1981

Language:

english

File:

PDF, 1.55 MB

english, 1981

42

Identification of Human Liver Cytochrome P450s Involved in the Microsomal Metabolism of the Antihistaminic Drug Loratadine

Yumibe, Nathan, Huie, Keith, Chen, Kwang-Jong, Clement, Robert P., Cayen, Mitchell N.

Journal:

International Archives of Allergy and Immunology

Year:

1995

File:

PDF, 327 KB

1995

43

The Penetration of Ceftibuten into the Respiratory Tract

Krumpe, Peter R., Colucci, Robert, Lin, Chin-Chung, Cayen, Mitchell, Affrime, Melton B.

Journal:

Critical Care Medicine

Year:

1995

File:

PDF, 759 KB

1995

44

Single-Dose Pharmacokinetics of Isepamicin in Young and Geriatric Volunteers

Nomeir, Amin A., Radwanski, Elaine, Cutler, David, Affrime, Melton, Christopher, David, Korduba, Chryzanta, Batra, Vijay, Lin, Chin-chung, Cayen, Mitchell N.

Journal:

Journal of Clinical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.41 MB

english, 1997

45

[Annual Reports in Medicinal Chemistry] Volume 15 || Chapter 17. Recent Developments in Lipoprotein Research and Antihyperlipidemic Agents

Cayen, Mitchell N.

Year:

1980

Language:

english

File:

PDF, 823 KB

english, 1980

46

MULTIPLE-DOSE PHARMACOKINETICS OF CEFTIBUTEN IN HEALTHY ADULTS AND GERIATRIC VOLUNTEERS

Radwanski, Elaine, Teal, Marilyn, Affrime, Melton, Cayen, Mitchell, Lin, Chin-Chung

Journal:

American Journal of Therapeutics

Year:

1994

File:

PDF, 422 KB

1994

47

Influence of Food on the Oral Bioavailability of Loratadine and Pseudoephedrine from Extended-Release Tablets in Healthy Volunteers

Nomeir, Amin A., Mojaverian, Parviz, Kosoglou, Teddy, Affrime, Melton B., Nezamis, Jim, Radwanski, Elaine, Lin, Chin-Chung, Cayen, Mitchell N.

Journal:

Journal of Clinical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.32 MB

english, 1996

48

The Organizational and Financial Viability of an Orthopedic Trauma Service

Harris, Mitchel B., Cayen, Barry

Journal:

The Journal of Trauma Injury Infection and Critical Care

Year:

2009

Language:

english

File:

PDF, 527 KB

english, 2009

49

Toxicokinetics: Its significance and practical problems.

KATO, Ryuichi, CASE, David E., HAKUSUI, Hideo, NODA, Kosei, SAGAMI, Fumio, HORII, Ikuo, MAYAHARA, Hiroshi, CAYEN, Mitchell N., MARRIOTT, Thomas B., IGARASHI, Toshiji

Journal:

The Journal of Toxicological Sciences

Year:

1993

File:

PDF, 2.71 MB

1993

50

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 14 Volume 14 || Chapter 19 Disorders of Lipid Metabolism

Cayen, Mitchell N.

Year:

1979

Language:

english

File:

PDF, 852 KB

english, 1979